"The working group of the Californian neurobiologist Pamela Maher has been researching the effect of fisetin on the central nervous system of mice and rats since the 2000s. The fundamental finding was that fisetin activates the extracellular regulated kinase (ECR) and thereby stimulates the proliferation of nerve cells Starting point of several experiments on brain function and its disorders, including neurodegenerative diseases. The administration of fisetin to genetically modified mice suffering from familial Alzheimer's disease slowed the progression of memory loss. A recent study was carried out with SAMP8 mice, whose neurons were excessive "Synthesize a lot of β-amyloid and serve as a model for non-familial Alzheimer's disease (SAMP = senescence accelerated mouse-prone)." (Quote from an article in Deutsche Apotheker-Zeitung)
"Fisetin is a senotherapeutic that extends health and lifespan
Senescence is a tumor suppressor mechanism activated in stressed cells to prevent replication of damaged DNA. Senescent cells have been demonstrated to play a causal role in driving aging and age-related diseases using genetic and pharmacologic approaches. We previously demonstrated that the combination of dasatinib and the flavonoid quercetin is a potent senolytic improving numerous age-related conditions including frailty, osteoporosis and cardiovascular disease. The goal of this study was to identify flavonoids with more potent senolytic activity." (https://pubmed.ncbi.nlm.nih.gov/30279143/)