David Sinclair: LifespanSmartphone users: If you have difficulties with navigation click here

Welcome to AFEGA Anti-Aging-Shop - Distributor & Wholesale Supply of NMN, NR, NAD+, Resveratrol/ Pterostilbene (We can also offer logistics to wholesale customers in the EU and CH)

A short remark about anti-aging:
So far, this mainly meant 'cosmetic products of often / most dubious effectiveness' - at least, if you would trust test reports. The expensive ointments worked for the day, worked when they had been applied fresh - after all! With the research results of Prof. Sinclair, a new era begins: 'Anti-Aging' no longer means 'improving the appearance'; from now on, anti-aging really means anti-aging, at least slowing down, but actually stopping or even reversing the aging process. The new 'anti-aging' starts at the roots, at the genes - and you can not get deeper, because below the level of the genes you can not talk about life anymore.

Genetic approaches to anti-aging

Sirtuins and NAD+

Prof. David Sinclair has conducted extensive research on sirtuins, a group of enzymes that play a key role in regulating the aging process. Sirtuins are activated by NAD+ (nicotinamide adenine dinucleotide), a molecule whose levels in the body decrease with age. By increasing NAD+ levels, sirtuins can be activated, leading to improved DNA repair, increased energy production in the mitochondria and an overall improvement in cellular function[1][3].

Epigenetic changes

Sinclair has also studied the role of epigenetic changes in the aging process. Epigenetic factors such as SIRT1 can be redistributed in response to DNA damage, leading to aging of cells. Through targeted epigenetic modulation, these changes can potentially be reversed, allowing cells to rejuvenate[1].

Xenohormesis

Another interesting concept is the xenohormesis hypothesis, which states that plant compounds produced under stress conditions can activate longevity mechanisms in animals and humans. Resveratrol, a polyphenol from grapes, is a well-known example of such a substance that activates SIRT1 and can thus extend lifespan[1][6].

Practical applications and products

NMN and NR

Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are precursors of NAD+ and have been shown in studies to increase NAD+ levels and thus reduce age-related loss of function in cells. These substances are already available as dietary supplements and are being intensively researched to confirm their effectiveness and safety in humans[3][6].

Resveratrol

Resveratrol is another example of a substance that intervenes deeply in the genetic mechanisms of aging. It activates sirtuins and has shown in studies that it can extend the lifespan of model organisms and combat age-related diseases such as Alzheimer's and cardiovascular diseases[6].

The anti-aging substances that we offer in our shop are based on the latest scientific findings and aim to influence the aging processes at the genetic and epigenetic level. By increasing NAD+ levels and activating sirtuins, as well as using botanicals such as resveratrol, these products have the potential to improve cellular function and extend lifespan. These profound approaches are significantly different from conventional cosmetic products and offer a science-based method to combat aging.

If NMN is a new topic for you or if you want to / have acquired it for the first time:
Please make sure  to read the FAQ !



Scources:

[1] https://sinclair.hms.harvard.edu/people/david-sinclair  
[3] https://www.harvardmagazine.com/2017/08/anti-aging-breakthrough  
[6] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9610014/

Citations:
[1] https://sinclair.hms.harvard.edu/people/david-sinclair
[2] https://www.wsj.com/health/wellness/
david-sinclair-longevity-aging-criticism-645fddc5
[3] https://www.harvardmagazine.com/2017/08/
anti-aging-breakthrough
[4] https://www.statnews.com/2024/03/05/
david-sinclair-harvard-longevity-scientist-reversing-aging-dogs/
[5] https://www.aging-us.com/news-room/
NEW-STUDY-Discovery-of-Chemical-Means-to-Reverse-Aging-and-Restore-Cellular-Function
[6] https://www.ncbi.nlm.nih.gov/pmc/articles/
PMC9610014/
[7] https://www.sciencedirect.com/science/article/
pii/S2468501119300379
[8] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5763529/
[9] https://www.mdpi.com/2227-9059/12/1/127
[10] https://www.pfizer.com/news/articles/
decoding_longevity_3_genes_linked_to_anti_aging

For up-to-date information on anti-aging and the pioneering research by (Harvard) Prof. David Sinclair, visit the Facebook page of the AFEGA Research Group and visit   our YouTube channel
WARNING: Be careful when buying NMN, especially from Amazon. Fraudsters cavort at Amazon and Alibaba, and neither Amazon nor Alibaba are taking effective action against it. But that's only the tip of the iceberg. NR (and other dietary supplements that are offered on Amazon) are also often simply fake. - You can find out more here.
AMAZON IS NOT TRUSTABLE! Learn more about a scandal: Accept more trash 

Bewertungen zu afega-anti-aging-shop.com


 

Our advice

1kg-Ca-AKG-Kapseln.jpg
TOP
1 kg Ca-AKG (2000 Capsules with 500 mg each)
​Calcium alpha-ketoglutarate Monohydrate
CAS 71686-01-6​

590,00 EUR
0,59 EUR per g
NMN Nikotinamidmononukleotid/Nicotinamide Mononucleotide
TOP
-20%

50g NMN powder,  purity > 99%, CAS 1094-61-7
Storage: NMN is stable at room temperature and has a shelf life of AT LEAST 2 years.

Please note the discount in the item description when buying (at least) 5 cans.

IMPORTANT: NMN is a chemical, not a nutritional supplement! It is not (yet) certified as such. Therefore we don't supply a  measuring spoon. If necessary, please order the inexpensive small digital scale.​

Only 47,92 EUR
0,96 EUR per g
50 g Micronized Resveratrol Powder Capsules
TOP
50 g NAC (N-Acetyl-L-Cystein), CAS 616-91-1
100 Capsules with 500 mg each
9,90 EUR
0,20 EUR per g
AA-NAC-Kapseln-250g
TOP
250 g NAC (N-Acetyl-L-Cystein), CAS 616-91-1
500 Capsules with 500 mg each
44,90 EUR
0,18 EUR per g
Anti Aging Face Cream with Q 10 and 5 % Nicotinamide
TOP
Anti Aging Face Cream with Q 10 and 5 % Nicotinamide (especially for mature skin)
​50 ml
24,50 EUR
Face Cream / Vanishing Cream with Q10 and 5% Nicotinamide
TOP
Face Cream/Vanishing Cream with Q 10 and 5 % Nicotinamide (The cream is suitable for all skin types.)
​50 ml
21,50 EUR
50 g CA-AKG (100 Capsules with 500 mg each)
TOP
50 g Ca-AKG (100 Capsules with 500 mg each)
​calcium alpha-ketoglutarate monohydrate
CAS 71686-01-6​

37,50 EUR
0,75 EUR per g
16 g NMN Powder in Jar
TOP
-10%

NMN Powder,> 99% Purity (CAS 1094-61-7) 
Storage: NMN is stable at room temperature and has a shelf life of AT LEAST 2 years. 

Only 21,60 EUR
1,35 EUR per g

Specials

Our goal is to be able to offer NMN, this 'miracle substance' at an affordable price. We work hard on that!
 

NMN Powder
TOP
-20%

250g NMN Powder (Nicotinamide Mononucleotide),> 99% Purity (CAS 1094-61-7) 
Storage: NMN is stable at room temperature and has a shelf life of AT LEAST 2 years. 

If you order more than 3 cans, please enter the discount code "nmn-1000" at checkout and you will receive a 15% discount on this item.
 

Only 199,20 EUR
0,80 EUR per g
Anti-Aging Substance - 20 g Pure NMN powder
-15%

20g NMN Powder (Nicotinamide Mononucleotide), < 99% Purity (CAS 1094-61-7) 
Storage: NMN is stable at room temperature and has a shelf life of AT LEAST 2 years. 

Please note:
We do not always purchase our own brand NMN from the same producer. We want to be able to offer this NMN as cheaply as possible and therefore negotiate the price with various producers. If the quality (especially the purity) meets our requirements, we then order from the producer who can deliver at the cheapest price.

If it is important to you that the properties of the NMN (color, consistency, granulation) are always exactly the same, please order the NMN from the UTHEVER brand.

Only 23,37 EUR
1,17 EUR per g
16 g NMN Powder in Jar
TOP
-10%

NMN Powder,> 99% Purity (CAS 1094-61-7) 
Storage: NMN is stable at room temperature and has a shelf life of AT LEAST 2 years. 

Only 21,60 EUR
1,35 EUR per g
99% Pure NMN Powder
TOP
-40%
16g NMN powder (Nicotinamide Mononucleotide), > 99% purity (CAS 1094-61-7) 
​Shelf life: 2 years



Only 8,94 EUR
0,56 EUR per g
1 KG Pure NMN Powder
TOP
-20%

1 kg NMN Powder (Nicotinamide Mononucleotide), > 99% Purity (CAS 1094-61-7) 
Storage: NMN is stable at room temperature and has a shelf life of AT LEAST 2 years. 

If you order at least 3 kg of NMN, please enter the discount code "NMN-3000" at checkout and you will receive a 10% discount on this item.

Only 636,00 EUR
0,64 EUR per g
NMN Nikotinamidmononukleotid/Nicotinamide Mononucleotide
TOP
-20%

50g NMN powder,  purity > 99%, CAS 1094-61-7
Storage: NMN is stable at room temperature and has a shelf life of AT LEAST 2 years.

Please note the discount in the item description when buying (at least) 5 cans.

IMPORTANT: NMN is a chemical, not a nutritional supplement! It is not (yet) certified as such. Therefore we don't supply a  measuring spoon. If necessary, please order the inexpensive small digital scale.​

Only 47,92 EUR
0,96 EUR per g
50 g NMN Powder
TOP
-7%

50 g NMN powder, purity > 99%, CAS 1094-61-7, 100 capsules 500 mg each
Storage: NMN is stable at room temperature and has a shelf life of AT LEAST 2 years.

Only 60,36 EUR
1,21 EUR per g

New product

25 g fisetin powder
NEW
TOP
25 g fisetin powder
Shelf life: 2 years



39,90 EUR
1,60 EUR per g
5g Apigenin-Kapseln
NEW
250 capsules of 100 mg each
CAS 29329900
Shelf life: 2 years



112,50 EUR
0,45 EUR per capsules
Liposomal-NMN-Powder
NEW
SOLD OUT

50g NMN powder,  purity > 99%, CAS 1094-61-7
Storage: NMN is stable at room temperature and has a shelf life of AT LEAST 2 years.

Composition:

70% NMN, 30% phospholipid (to form the liposome)

Savings potential
Due to the revolutionary manufacturing method, 500 mg are sufficient instead of the daily dose of one gram usually recommended by Prof. Sinclair.

59,90 EUR
1,20 EUR per g
Liposomal-NMN-Powder
NEW
SOLD OUT

50g NMN powder, purity > 99%, CAS 1094-61-7, 100 capsules of 500 mg each
Storage: NMN is stable at room temperature and has a shelf life of AT LEAST 2 years.

Composition:
350 mg NMN, 150 mg phospholipid (to form the liposome)

Savings potential
Due to the revolutionary manufacturing method, 1 capsule of 500 mg is sufficient instead of the daily dose of one gram usually recommended by Prof. Sinclair.

64,90 EUR
1,30 EUR per g
Liposomales Q10
NEW
SOLD OUT
Liposomal Coenzyme Q10 Powder - 10 g pure powder

Composition:
70% Q10
15% dextrin
15% phospholipids

(Recommended consumption: 143 mg, corresponding to 100 mg Q10)

A measuring spoon is included, but it is recommended to order this inexpensive digital scale:


29,90 EUR
100 g fisetin powder
NEW
TOP
100 g fisetin powder, CAS 528-48-3
Shelf life: 2 years



125,00 EUR
1,25 EUR per g
Liposomales Q10
NEW
SOLD OUT
60 capsules each containing 143 mg liposomal Q10

Composition:
70% Q10
15% dextrin
15% phospholipids

(Recommended consumption: 1 capsule per day, corresponding to 100 mg Q10)
39,90 EUR